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Written by Will Reiser who based the film on his own experiences fighting cancer, Jonathan Levine's poignant comedy 50/50 stars Joseph Gordonn-Levitt as Adam, a 27-year-old public-radio employee who discovers he has cancer. As his best friend Kyle (Seth Rogen) tries to help out, his girlfriend Rachael (Bryce Dallas Howard) proves to be a less than ideal life partner for this particular crisis. All the while, Adam's overprotective mother Diane (Anjelica Huston) tries to overcome her son's continued attempts to keep her out ...

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